top of page

ABOUT THE AUTHOR

I have a PhD in bio-medical anthropology became bored with Academia and repackaged my problem-solving skills to become an expert in pharmaceutical New Product Planning and Strategic Marketing that led to becoming Senior Vice President of Global Strategy for one of the top Swiss Pharma companies. In my professional role, I developed a strong interest in personalized medicine and a passion for its implementation. I was involved in a pharmaceutical company’s acquisition of a diagnostics group in the late 1990’s to accelerate implementation of personalized medicine. Recently, I wrote a business plan for the implementation of personalized medicine for a G7 country.

I’m a native of Berkeley, California, and live there today. I got my BA in anthropology from the University of California and went on to graduate school at the University of Pennsylvania, which I thought was another state school. Budding anthropologists have to choose where to do fieldwork. In my case, I looked for the amalgam of beaches, tropics, and French food. I won my personal trifecta in the then New Hebrides (now Vanuatu). I was fortunate to study with the discoverer of the hepatitis B virus.

Elizabeth Reed Aden

Search

betsyaden
- Jul 10, 2022
- 1 min read

Genes, SNPs & THC

Genetics seems to play an important role at each step in the body’s processing of cannabis, especially THC. It’s important to put SNPs into perspective. Lots of studies have been done looking for SNPs correlated with disease. There are studies that show an effect and studies that don’t. In my opinion, I thinks this highlights that more factors, genetic or environmental, are probably involved. That said, I like to think of a positive results as a signal that the SNP could be involved but it is not a simple one gene one disease phenomenon. Supporting this complexity is that many associations differ by ethnicity and geography.

Below is a key article that reviews the Genes and SNPs associated with THC use. It is an excellent reference.

Hryhorowicz et al 2018 Eur J Drug Metab - Pharmacogenetics of Cannabinoids

.pdf

Download PDF • 682KB

Other articles that elaborate on the Genes and SNPs that are involved in THC metabolism (Miguel-Yanes), the role in neurobiology of the cannabinoid receptor (Lutz; Onaivi) and an overview of the endocannabinoid system (Battista) are available below:

Battista et al 2012 Front BehavNeurosci - EC system - Overview

.pdf

Download PDF • 1.06MB

Lutz 2020 DialoguesClinNeurosci-Neurobio CBR Signaling

.pdf

Download PDF • 1.76MB

Miguel-Yanes et al 2011 Obesity - CB1 Variants

.pdf

Download PDF • 727KB

Onaivi et al 2012 J Psychopharmacol - CNS of CB2

.pdf

Download PDF • 437KB

Recent Posts

Personalized Health – Genes & Groceries

Who would ever think that one change the DNA of a gene could affect what you like to eat, what you can eat, what tastes good to you, does your body benefit from your diet, or “foods” that can be addic

Nutrigenetics, Nutrigenomics, SNPs & You

For foods, herbs, supplements and diets--like pharmaceuticals--"one size does not fit all". There is a Goldilocks Effect for much of what we ingest. One of the keys to finding out if you are on the

Access Your DNA & SNPs

An overview of the genes and their single nucleotide polymorphisms (SNPs), or variants, that may affect the biology of THC for an individual. The first step is to get your DNA analyzed. Below is a si

bottom of page